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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2013 Apr 1;21(11):3164–3174. doi: 10.1016/j.bmc.2013.03.059

Table 2.

Stimulation of [35S]GTPγS binding to cloned human D2 and D3 receptors expressed in CHO cells

D-compound hCHO-D2 hCHO-D3
EC50 (nM) Emax (%) EC50 (nM) Emax (%) D2/D3
Dopamine 227 ± 11a 100 7.64 ± 0.56 100 26.6
D-301a 116 ± 16 88.4 ± 3.9 0.82 ± 0.20 102 ± 2 141
D-440c 114 ± 12 101 ± 5 0.26 ± 0.07 103 ± 10 438
(−)-15 D-237b 2.22 ± 0.27 63.4 ± 3.5
(−)-16b D-399 Not active Not active
(+)-9d D-515 179 ± 47 36.8 ± 8.7 30.3 ± 6.4 58.6 ± 4.8
(+)-14f D-532 Not active Not active

EC50, the concentration producing half-maximal stimulation, is shown as the mean ± SEM for three to four experiments, each performed in triplicate.

a

From our previous work.23

b

From our previous work.22

c

From our previous work.24