Table 4.
The association of the top three genetic loci in SNP-phenotype associations VLDL particle diameters response to fenofibrate with VLDL subfraction concentration responses to fenofibrate
| Marker | Large VLDL
|
Medium VLDL
|
Small VLDL
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| β (SE) | P | Q | β (SE) | P | Q | β (SE) | P | Q | |
| rs11766298 | 1.86 (0.78) | 0.02 | 0.06 | −1.40 (0.77) | 0.07 | – | −1.12 (0.90) | 0.21 | – |
| rs10428959 | 3.58 (1.14) | 0.002 | 0.01 | −1.32 (1.16) | 0.26 | – | −1.02 (1.39) | 0.46 | – |
| rs6466397 | −3.58 (1.14) | 0.002 | 0.01 | 1.31 (1.16) | 0.26 | – | 1.02 (1.39) | 0.46 | – |
SNPs, single nucleotide polymorphisms; VLDL, very low-density lipoprotein.