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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Pharmacogenet Genomics. 2012 Oct;22(10):750–757. doi: 10.1097/FPC.0b013e328357f6af

Table 5.

The association of the top three genetic loci in SNP-phenotype associations LDL particle diameters response to fenofibrate with LDL subfraction concentration responses to fenofibrate

Marker Large LDL
Medium–small LDL
Small LDL
Very small LDL
β (SE) P Q β (SE) P Q β (SE) P Q β (SE) P Q
rs10952132 0.29 (0.65) 7.31 × 10−6 3.00 × 10−5 −0.16 (0.69) 0.02 0.02 −0.29 (0.07) 2.26 × 10−5 4.8 × 10−5 −0.29 (0.07) 4.13 × 10−5 6.85 × 10−5
rs10995485 −1.04 (0.25) 3.35 × 10−5 6.00 × 10−5 1.12 (0.25) 1.16 × 10−5 3.00 × 10−5 0.82 (0.26) 0.002 0.002 0.75 (0.27) 0.006 0.007
rs519595 −0.58 (0.13) 5.02 × 10−6 3.00 × 10−5 0.44 (0.14) 0.001 0.001 0.58 (0.13) 1.17 × 10−5 3.00 × 10−5 0.52 (0.14) 0.0002 3.00 × 10−4

LDL, low-density lipoprotein; SNPs, single nucleotide polymorphisms.