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. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Biomed Chromatogr. 2013 Mar 10;27(7):900–909. doi: 10.1002/bmc.2880

Table 3.

The pharmacokinetic parameters of 13–197 in mice and in rats after 5 mg/kg intravenous and 50 mg/kg oral doses (N=5).

PK Parameters	Mice		Rat
PK Parameters	IV dose- 5mg/kg	Oral Dose- 50mg/kg	IV dose- 5mg/kg (Mean ± SEM	Oral dose- 50mg/kg (Mean ± SEM)

T_max (h)	* ^a)	1.0	*	12.0 ± 4.0
C_max(ng/ml)	*	340.2	*	1049.5 ± 195.1
AUC_last (ng.h/ml)	3848	1184	13819 ± 5693	22168 ± 5455
AUC_0-∞ (ng.h/ml)	3879	1219	13848 ± 5683	22170 ± 5454
λ_z (1/h)	0.044	0.1623	0.087 ± 0.020	0.138 ± 0.005
t_0.5(h)	15.7	4.3	9.4 ± 2.1	5.0 ± 0.18
V_β (l/kg)	29.26	252.5	7.5 ± 2.5	21.2 ± 3.4
CL (l/hr/kg)	1.28	40.99	0.50 ± 0.11	2.96 ± 0.53
MRT_0-∞ (h)	5.14	4.4	5.7 ± 1.0	14.1 ± 1.7
V_ss (l/kg)	6.6	*	2.99 ± 1.06	*
% bioavailability	*	3.14	*	16.03

^a)

not applicable