Table 4.

Concentrations of 13–197 in mouse and rat tissues after 5 mg/kg intravenous dose and 50 mg/kg oral dose (N=5, Mean ± SEM).

Tissue	Time	IV-5mg/kg ng/g tissue	Oral-50 mg/kg ng/g tissue
Mice
Liver	8 h	12262 ± 2601	209 ± 21
	72 h	1548 ± 143	3.0 ± 0.7
Lung	8 h	48217 ± 15521	61 ± 4.7
	72 h	4901 ± 1116	1.3 ± 0.9
Kidney	8 h	613 ± 45	113 ± 20
	72 h	346 ± 50	2.4 ± 0.8
Spleen	8 h	8859 ± 2718	30 ± 6.4
	72 h	1538 ± 96	1.9 ± 0.8
Heart	8 h	3205 ± 1033	69 ± 10
	72 h	404 ± 32	6.7 ± 2.6
Brain	8 h	67 ± 21	1.13 ± 0.16
	72 h	5.6 ± 1.1	<LLOQ
Rat
Liver	72 h	43 ± 25	7.0 ± 2.5
Kidney	72 h	196 ± 108	20 ± 7.7
Lung	72 h	52 ± 24	7.0 ± 2.0
Spleen	72 h	39 ± 18	9.4 ± 3.7
Heart	72 h	23 ± 11	4.4 ± 1.9
Brain	72 h	93 ± 53	0.8 ± 0.2