Figure 4.

Differences in energy between active (Anisotropic Network Model based) and inactive (rhodopsin crystal-structure based) models of mGluRs. Green bars indicate positive modulators, red bars negative modulators and the yellow bar represents a neutral ligand. Where values of 2 are shown, the ligand did not dock to the active model, where values of −2 are shown, the ligand did not dock to the inactive model. Error bars indicate standard deviation in three docking experiments each for the respective active and inactive models. If an error bar is placed at a −2 or 2 bar, the error represents the standard deviation of the ligand and model combination where docking was observed. A. Results from docking with Autodock software. B. Results from docking with ArgusLab software. Image is adapted from [72].