Table 1.

Comparative trials of HCC staging systems in the past 5 years

Author	Year	Number of patients	Staging system	Treatment	Method	Favor of the staging system
Kim [114]	2012	1717	BCLC, JIS, Tokyo, CLIP, CUPI, GETCH	Multiple	prospectively	BCLC: prognosis
Sirivatanauksorn [115]	2011	99	TNM, CLIP, BCLC, CUPI, JIS, Okuda	Hepatectomy	retrospectively	TNM and Child-Pugh: representative survival prediction
Chan [116]	2011	595	TNM, CLIP, BCLC, CUPI	NA	prospectively	CUPI: for HBV-related HCC. CUPI and CLIP offer good risk stratification for advanced HCC
Kawaoka [117]	2010	214	mJIS, JIS, BCLC, LCSGJ/TNM, CLIP	TACE	retrospectively	mJIS: better discriminate ability score and prognostic predictive power
Hsu [118]	2010	1713	BCLC, CLIP, JJIS, TNM, Tokyo	NA	prospectively	CLIP: best long-term prognostic model
Huitzil-Melendez [119]	2010	187	BCLC, TNM, CLIP, CUPI, GETCH	NA	retrospectively	CLIP, CUPI, and GETCH: survival prediction
Zhang [120]	2010	306	TNM, Okuda, CLIP, BCLC, JIS	Hepatectomy	retrospectively	BCLC: strongest potential in prognosis evaluation
Chung [121]	2008	290	JIS, BCLC, Tokyo	Radical treatment	retrospectively	JIS: best prognostic stratification
Lu [122]	2008	234	Okuda, CLIP, TNM, CUPI	Curative resection	retrospectively	TNM: best for prognostic stratification and prognosis prediction.
Camma [123]	2008	406	BCLC, CLIP, GETCH	LT or none	prospectively	CLIP: best discriminative capacity BCLC: predicting survival in treated patients
Collette [124]	2008	538	Okuda, CLIP, BCLC	Palliative treatment	randomized	CLIP: prognosis
Cho [125]	2008	131	Child-Pugh, Okuda, BCLC, CLIP, mCLIP, JIS, mJIS	TACE	retrospectively	CLIP for palliative setting
Guglielmi [126]	2008	112	Okuda, TNM, BCLC, CLIP, GETCH, CUPI, JIS	percutaneous RFA	retrospectively	BCLC: superior discriminatory power and prognostic information
Kondo [127]	2007	235	CLIP, BCLC, GETCH, CUPI, JIS, mJIS, Tokyo	Hepatectomy	retrospectively	JIS
Chen [128]	2007	382	Okuda, AJCC, CLIP, BCLC, JIS, CUPI, MELD	Hepatectomy	retrospectively	CLIP: stage major hepatectomy patients, JIS: stage minor hepatectomy patient

NA= not available.