Table 5.
Gastrointestinal absorption of pinitol and [2H6]d-chiro-inositol (DCI) in rats fed Basal Diet 5755* (Mean values with their standard errors)
| Dietary intake | Fecal output | Urinary output | Total output | |||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Pinitol feeding | ||||||||
| Total DCI (μmol/kg body weight per d) | ||||||||
| Pre-pinitol | 0.09 | 0.02 | 0.07 | 0.02 | 0.48 | 0.31 | 0.54 | 0.31 |
| Pinitol, Day 1 | 122 | 7.4 | 1.11 | 0.53 | 26.0 | 1.7 | 27.11 | 0.56 |
| Pinitol, Day 2 | 0.07 | 0.01 | 0.10 | 0.01 | 0.38 | 0.11 | 0.47 | 0.12 |
| [2H6]DCI Feeding Free [2H6]DCI (nmol/kg body weight per d) |
||||||||
| Day 1 | 59.1 | 3.6 | 0.15 | 0.1 | 4.0 | 0.4 | 4.2 | 0.2 |
| Day 2 | ND | 1.0 | 1.0 | 4.3 | 0.1 | 5.3 | 1.1 | |
ND, not detectable.
Three rats weighing 427 ± 27 g were housed individually in metabolic cages and fed Purina Basal Diet 5755 for 3 d. Pinitol, 51.5 μmol (10 mg), was given orally with urine and stools collected for the following 2 d, which were analyzed for total DCI. Then 25 nmol [2H6]DCI was given orally, followed by an additional 2 d of urine and stool collection. No [2H6]DCI was detectable before isotope administration.