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. Author manuscript; available in PMC: 2013 Sep 3.
Published in final edited form as: Nature. 2011 Aug 24;477(7362):61–66. doi: 10.1038/nature10362

Figure 2. The Get2 fragment complex with ADP•AlF4--bound Get3.

Figure 2

(a) Predicted topology of S. cerevisiae Get2 with large cytosolic-facing region (yellow). (b) Structure of two Get2 fragments (yellow) bound to the closed Get3 dimer (green, blue). Two Mg2+ADP•AlF4- complexes and a zinc atom are indicated (spheres). An orthogonal view into the substrate-binding composite hydrophobic groove is shown on the right. (c) Get3 residues in the Get2 interface are indicated; most contacts are to one Get3 monomer (green). (d) Closeup of interactions along helix α1 of Get2, including R17, K20 and F21. (e) Closeup of interactions along helix α2 of Get2, including the conserved salt bridge between R29 and E253.