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. Author manuscript; available in PMC: 2013 Sep 3.
Published in final edited form as: Nature. 2011 Aug 24;477(7362):61–66. doi: 10.1038/nature10362

Figure 3. The Get1 fragment complex with Get3.

Figure 3

(a) Predicted topology of S. cerevisiae Get1 with large cytosolic-facing region (magenta). (b) Structure of two Get1 fragments (magenta) bound to the open dimer state of Get3 (green, blue). The composite hydrophobic groove is completely disrupted. (c) Get3 residues in the Get1 interface are indicated; significant contacts are made to both monomers (green, blue). (d) Closeup of interactions between Get1 helix α2 (magenta) and one Get3 monomer (green), including the conserved salt bridge between R73 and E253. This interface overlaps extensively with the Get2c binding surface (see Fig. 2e and S11). (e) Closeup of interactions between the Get1 hairpin loop and the active site of the adjacent Get3 monomer (blue).