Table 2.

Proteins regulated by CXCL13 and their relevant biological functions in PC3 cells.

OP	Molecules	p-value
Growth of tumor cell lines	AKT1, AKT2, BAD, BCL2, BCL2L1, CAV1, CDC2, CDK2, ELK1, JUN, MAPK3, MAPK8, NF2, PTK2, RAF1, SRC, STMN1	1.11E-09
Proliferation of tumor cell lines	AKT1, AKT2, BAD, CAV1, GJA1, ITGB3, JUN, JUNB, LIMK1, MAPK3, MAPK8, PDPK1, SRC	6.66E-08
Anti-Apoptosis	AKT1, AKT2, BAD, BCL2, BCL2L1, CAV1, CDC2, ITGB3, JUN, MAPK3, MAPK8, PDPK1, PTK2, SRC, STMN1, VAV1	4.26E-07
Prostate carcinoma	AKT1, AKT2, CDC2, CDK2, ITGB3, JUN, RAF2, SRC	9.16E-07
Metastasis	AKT1, ITGB3, NF2, PTK2, RELA, SRC	9.29E-07
Cell cycle progression	BCL2, CAV1, CDC25C, CDK2, MAPK8, RAF1, VAV1	1.85E-05
Survival of tumor cell lines	AKT1, AKT2, BCL2, BCL2L1, CAV1, CDK2, CDKN1A, CDKN1B, CHEK1, CHEK2, CREB1, EGFR, ERBB2, FRAP1, JAK1, MET, NFKB1, NFKB2, NTRK2, PDGFRB, PRKAA1, PTK2, RELA, RELB, SRC, STAT3	2.05E-05

Phosphorylation-specific antibody microarrays were used to monitor active and inactive protein levels in PC3 cells following CXCL13 stimulation. The resulting profiles were analyzed and clustered into known biological functions and diseases to better understand the underlying mechanisms involved in CXCL13-induced signaling molecules in prostate cancer. The p-values were calculated using Fisher’s exact test and indicate the probability of the involvement of these molecules in a given network associated with biological functions and diseases.