Table 4.
Outcome according to TIMI 3 flow before percutaneous coronary intervention in two treatment groups
| Pre-PCI TIMI 3 |
Pre-PCI TIMI <3 |
|||||
|---|---|---|---|---|---|---|
| Primary PCI (n=124) | TNK+PCI (n=353) | p-value | Primary PCI (n=689) | TNK+PCI (n=451) | p-value | |
| Complete 60 min ST-segment resolution (post PCI) (n=with 60 min ECG) | 39.3 (n=89) | 38.4 (n=258) | 0.873 | 11.1 (n=505) | 14.9 (n=329) | 0.106 |
| TIMI 3 patency after PCI | 95.1 | 95.7 | 0.786 | 87.8 | 82.9 | 0.025 |
| Complete 180 min ST-segment resolution (post PCI) (n=with 180 min ECG) | 61.9 (n=97) | 57.5 (n=287) | 0.451 | 51.0 (n=561) | 45.9 (n=362) | 0.128 |
| 30-day outcome | ||||||
| Death | 3.2 | 3.7 | 1.000 | 3.6 | 6.7 | 0.020 |
| Cardiogenic shock | 2.5 | 3.4 | 0.769 | 4.5 | 7.9 | 0.020 |
| CHF | 9.1 | 9.3 | 0.952 | 8.7 | 12.0 | 0.068 |
| Reinfarction | 2.4 | 6.0 | 0.119 | 2.9 | 4.9 | 0.079 |
| Major bleeding | 4.0 | 4.0 | 0.974 | 4.6 | 6.7 | 0.144 |
| Composite (death/shock/CHF) | 12.1 | 12.8 | 0.843 | 11.6 | 18.8 | 0.001 |
| 90-day outcome | ||||||
| Death | 4.0 | 4.0 | 0.992 | 4.5 | 7.6 | 0.032 |
| Cardiogenic shock | 2.5 | 4.1 | 0.425 | 4.6 | 8.2 | 0.013 |
| CHF | 9.1 | 9.9 | 0.807 | 9.0 | 13.9 | 0.011 |
| Reinfarction | 3.2 | 7.0 | 0.133 | 3.4 | 5.7 | 0.066 |
| Composite (death/shock/CHF) | 12.1 | 13.8 | 0.641 | 12.7 | 21.2 | <0.001 |
| Stroke | ||||||
| ICH | 0 | 1.1 | 0.234 | 0.1 | 0.9 | 0.064 |
| Ischaemic | 0 | 1.1 | 0.234 | 0 | 1.1 | 0.006 |
| Unknown cause | 0 | 0.3 | 0.553 | 0 | 0.7 | 0.032 |
Values are%. CHF, congestive heart failure; ICH, intracerebral haemorrhage; PCI, percutaneous coronary intervention; TIMI, thrombolysis in myocardial infarction; TNK, tenecteplase.