Table 2.
Clinical characteristics by serum uric acid group (cut off 6.25 mg/dl).
| Increased uric acid (n=206) | Normal uric acid (n=477) | p-value | |
|---|---|---|---|
| Age (years) | 67±13 | 63±13 | <0.001 |
| Male gender | 70.4 | 68.6 | 0.699 |
| BMI (kg/m2) | 28±5 | 26±4 | <0.001 |
| Risk factors (%) | |||
| Hypertension | 73.8 | 63.7 | 0.013 |
| Hyperlipidaemia | 46.6 | 53.2 | 0.131 |
| Diabetes | 32.0 | 21.8 | 0.006 |
| Smoking | 31.6 | 41.5 | 0.018 |
| Previous history | |||
| Myocardial infarction | 25.7 | 15.3 | 0.002 |
| PCI | 12.6 | 10.9 | 0.605 |
| CABG | 8.7 | 3.8 | 0.013 |
| Stroke/TIA | 8.7 | 6.5 | 0.379 |
| Initial presentation | |||
| STEMI | 57.8 | 63.3 | 0.208 |
| Killip class ≥2 | 33.5 | 15.1 | <0.001 |
| Heart rate (bpm) | 84±21 | 76±18 | <0.001 |
| Systolic blood pressure (mmHg) | 138±32 | 136±29 | 0.399 |
| Laboratory data | |||
| Admission blood glucose (mg/dl) | 141 (114–199) | 133 (110–177) | 0.087a |
| Peak CK (IU/l) | 960 (318–2472) | 1167 (365–2792) | 0.221a |
| Admission creatinine (mg/dl) | 1.26±0.48 | 0.91±0.28 | <0.001 |
| eGFR <60 ml/min/1.73 m2 | 40.3 | 29.6 | 0.008 |
| GRACE risk score | 153±37 | 136±32 | <0.001 |
| LVEF <35% | 11.2 | 3.8 | <0.001 |
| PCI at index hospitalization | 83.2 | 68.0 | <0.001 |
| All-cause mortality | |||
| In-hospital mortality | 9.2 | 2.5 | <0.001 |
| 30-day mortality | 9.7 | 3.6 | 0.002 |
| 1-year mortality | 15.5 | 4.2 | <0.001 |
Values are mean±SD, %, or median (IQR).
a
Mann–Whitney test.
BMI, body mass index; CABG, coronary artery bypass grafting; CK, creatine kinase; eGFR, estimated glomerular filtration rate; GRACE, Global Registry of Acute Coronary Events; LVEF, left ventricular ejection fraction; PCI, percutaneous coronary intervention; STEMI, ST-elevation myocardial infarction; TIA, transient ischaemic attack.