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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Synapse. 2013 May 30;67(10):668–677. doi: 10.1002/syn.21671

Fig. 3. Effects of novelty on locomotor activity in DAT-LE and WT mice.

Fig. 3

Naïve animals were placed in open-field chambers on day 1, and their locomotor activity in the novel environment was recorded for 90 min (mean values ± SEM; N = 18/genotype). Subsequently, all of the mice were injected with saline; and their behavior was monitored for an additional 60 min (see Fig. 4). On day 2 their activity in the open-field was again monitored for the initial 90 min, prior to being injected with either saline or cocaine (see Fig. 4). (A) Time course of distance traveled during the first 90 min in the chamber by WT and DAT-LE mice day 1 (left panel) and day 2 (right panel). ***p<0.001, DAT-LE vs WT (B) Total distance traveled by the two genotypes in the first 30 min (novelty) in the chamber on days 1 and 2. ***p<0.001, DAT-LE vs WT.