. Author manuscript; available in PMC: 2013 Sep 3.

Published in final edited form as: Nat Rev Drug Discov. 2012 Dec;11(12):937–957. doi: 10.1038/nrd3871

Table 3.

Peptides derived from unique sequences in PKC (6–10 amino acids in length) exert isozyme-selective effects in a number of animal models of human diseases.

Peptide (isozyme; Swissprot #; site)	Peptide sequence	Selectivity ^reference	Biological effects: examples of diseases and models^reference
βC2–4 (human PKCβ; PO5771; amino acids 218–226)	SLNPEWNET	Affects all cPKCs²⁵³	Inhibits cardiac hypertrophy in culture²⁵³
δV1-1 (mouse PKCδ; P28867; amino acids 8–17)	SFNSYELGSL	Selectively inhibits PKCδ²⁸	Reduces infarct size when given at reperfusion, after myocardial infarction (MI)^28,192; Inhibits breakdown of blood/brain barrier in hypertensive rats²⁵⁷
εV1–2 (rat PKCε; P09216; amino acids 14–21)	EAVSLKPT	Selectively inhibits PKCε²²⁴	Prevents transition to heart failure in hypertensive rats²³⁷; Inhibits pain sensation in an inflammatory pain model in rats⁴⁴
βIIV5-3 (human PKCβ; P05771-2; amino acids 612–617)	QEVIRN	Selectively inhibits PKCβII^108,94	Prevents cardiac dysfunction and death in a rat model of post-MI heart failure¹⁰⁹; inhibits neo-angiogenesis in a xenograft model of prostate tumor in mice⁹⁴
γV5-3 (human PKCγ; P05129; amino acids 659–664)	RLVLAS	Selectively inhibits PKCγ⁴⁴	Prevents pain by blocking transmission in the cord⁴⁴
αV5-3 (human αPKC; P17252; amino acids 642–647)	QLVIAN	Selectively inhibits PKCα²⁵⁸	Inhibits PKCα and inhibits tumor metastasis²⁵⁸
ψε RACK (rat PKCε; P09216; amino acids 85–92)	HDAPIGYD	Selectively activates PKCε by inhibiting auto-inhibitory intra-molecular interaction²⁵⁶	Induces protection from ischemic event when given prior to MI^256,259