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Adenine-induced stellation is dependent on PKA and Rac-1 and is not dependent on the adenosine A2a receptor. The degree of adenine-induced stellation was significantly reduced in the presence of PKA (ST-HT31) and rac-1 (NSC23766) inhibitors. The exposure to a adenosine A2a receptor inhibitor (ZM 241385) did not reduce the ability of adenine to induce stellation. All experiments were repeated at least four times
