. 2013 May 9;144(3):981–989. doi: 10.1378/chest.12-1404

Table 3.

—Population Trends for Physical HRQOL Domains

Variables	Physical Functioning	Body Image	Eating Disturbances	Digestive Symptoms	Respiratory Symptoms	Weight	Health Perception	Vitality
Subjects, No.	278	278	277	277	277	277	278	278
Observations, No.	1,444	1,447	1,443	1,442	1,440	1,435	1,442	1,449
Intercept	53.67^a	42.45^a	76.99^a	77.82^a	41.62^a	20.26^b	43.48^a	47.47^a
Time, y	…	…	…	…	…	…	…	…
Design	−3.05	−2.67	0.52	−6.48	−2.61	−6.01	−3.25	−6.37
Sociodemographic
Age	−0.52^a	−0.06	−0.11	−0.12	0.05	−0.03	−0.20	−0.12
Female	−12.69^a	9.80^a	−4.26	−2.25	−3.98	10.17^b	0.43	−4.26^c
Higher education	2.50	3.92	2.18	4.95^c	0.29	5.52	1.76	1.99
Clinical
FEV₁ % predicted	0.46^a	0.10^c	0.14^b	…	0.26^a	0.32^a	0.27^a	0.16a
Weight %	…	0.25^a	0.10^b	…	…	0.62^a	0.08^c	…
Pancreatic sufficient	…	13.18^c	…	9.00^c	…	…	…	…
No. exacerbations	−3.10^a	−1.56^a	−2.22^a	…	−1.32^b	−3.07^a	−1.66^a	−2.11^a
Pseudo-R²	0.25	0.19	0.05	0.03	0.08	0.26	0.10	0.04

Models were adjusted for a design variable (a dichotomous indicator based on predicted probability of 5-y survival of 0.975 or higher). The presence of CF-related diabetes and the presence of Staphylococcus aureus, Burkholderia cepacia, and Pseudomonas aeruginosa were not statistically significant predictors of any of the physical HRQOL domains; therefore, these variables were deleted from all the models using a stepwise procedure. Other clinical variables were also deleted from the final models when nonsignificant. No interaction terms with time were included in the models for the HRQOL physical domains because there were no significant linear trends for any of these variables. See Table 1 and 2 legends for expansion of abbreviations.

P < .001.

P < .01.

P < .05.