Table 5.

—Population Trends for Psychosocial HRQOL Domains

Variables	Role Functioning	Treatment Burden	Emotional Functioning	Social Functioning
Subjects, No.	278	278	278	277
Observations, No.	1,441	1,443	1,448	1,441
Intercept	67.76a	37.52a	62.06a	74.97a
Time, y	…	8.89b	3.22b	−2.42a
Design	−6.13	−0.93	−1.00	1.71
Sociodemographic
Age	−0.20	0.30c	0.06	−0.35a
Female	−2.90	−2.31	1.30	−2.97
Higher education	5.13c	−1.76	6.26c	1.41
Clinical
FEV1 % predicted	0.22a	0.17b	…	…
Weight %	…	…	…	…
Pancreatic sufficient	…	…	…	9.66b
No. exacerbations	−4.16a	−1.14c	−1.27b	−1.03b
Interaction terms
Age × time	…	−0.15c	…	…
Female × time	…	…	…	…
Post-high school degree × time	…	…	−3.28c	…
FEV1 % predicted × time	…	−0.11b	…	…
Pseudo-R2	0.12	0.04	0.03	0.03

Models were adjusted for a design variable (a dichotomous indicator based on predicted probability of 5-y survival of 0.975 or higher). The presence of CF-related diabetes and the presence of Staphylococcus aureus, Burkholderia cepacia, and Pseudomonas aeruginosa were not statistically significant predictors of any of the psychosocial HRQOL domains; therefore, these variables were deleted from all the models using a stepwise procedure. Other clinical variables were also deleted from the final models when nonsignificant. Interaction terms with time were included in the models for which a significant time trend was found. Only statistically significant interaction terms are included in the table, because nonsignificant interaction terms were removed from the models using a stepwise procedure. See Table 1 and 2 legends for expansion of abbreviations.

^aP < .001.

^bP < .01.

^cP < .05.