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. Author manuscript; available in PMC: 2013 Sep 3.
Published in final edited form as: BMB Rep. 2012 Jan;45(1):7–13. doi: 10.5483/bmbrep.2012.45.1.7

Fig. 2. Proposed piRNA biogenesis complex in mice.

Fig. 2

MitoPLD localized on the mitochondrial surface hydrolyzes cardiolipin to generate PA, a negatively-charged lipid, which may promote nuage complex formation either by recruiting the positively-charged nuage via electrostatic attraction, by anchoring a nuage-localized PA-binding protein, or by affecting piRNA precursor or mitochondrial trafficking along microtubules. GASZ co-localizes with mili, MVH, TDRD1, RanBP9, or MIWI depending on the stages of spermatogenesis. The piP-body contains Mael, MIWI2 and TDRD9 and physically interacts with nuage/the pi-body. See text for additional details.