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. 2013 Sep 3;8(9):e73902. doi: 10.1371/journal.pone.0073902

Figure 4. Deletion of huntingtin in mature neurons alters hippocampal Akt and Erk phosphorylation without affecting BDNF production.

Figure 4

(A) Representative Western-blots of hippocampal proteins extracted from mutant and control mice 6 months after being injected with tamoxifen and incubated with phospho-ERK, ERK, phospho-Akt, Akt, BDNF or actin recognizing antibodies. (B–D) Data are the mean +/- SEM of the ratios phospho-ERK/ERK, phospho-Akt/Akt, mature BDNF/actin obtained by Western-blot densitometric analysis, normalized so that the mean value of controls is equal to 1 (n= 4-5 per group). * p<0.05 ** p<0.01 *** p<0.005.