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. 2013 Sep 3;8(9):e73663. doi: 10.1371/journal.pone.0073663

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© 2013 Takeuchi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Examination of sex differences in the expression of cell life cycle-related genes as well as cyp19a1b in the medaka optic tectum (A) and its size (B). (A) Examination of sex differences in the expression of cyp19a1b, proliferation markers, pcna and mki67, genes indicative of multipotency, sox2 and msi1, mature radial glial marker, gfap, anti-apoptotic genes, bcl2 and bcl2l1, and pro-apoptotic genes, baxa and baxb, in the medaka optic tectum. Values are given relative to the level of expression in the whole brain of males, which was arbitrarily set to 1. *, p < 0.05; **, p < 0.01; ***, p < 0.001. (B) Examination of sex differences in the optic tectum size in medaka. No significant difference was detected between males and females (p = 0.12).