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. 2013 Sep 3;8(9):e72816. doi: 10.1371/journal.pone.0072816

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© 2013 Chanakul et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fgf-23^+/+/1α-Luc^+/− (wt), fgf-23^+/−/1α-Luc^+/− (het) and fgf-23^−/−/1α-Luc^+/− (ko) mice were bred as described in Methods. Mice were sacrificed at 4 weeks of age, the heart and aorta removed and divided into two parts for determination of CYP27B1 promoter activity in heart (A), and aorta (B), expressed as luciferase activity per mg of tissue. Graph depicts fold change with respect to luciferase activity in fgf-23^+/+/1α-Luc^+/− mice. CYP27B1 mRNA expression in heart (C), and aorta (D), quantitated by real-time PCR, normalized to that of gus mRNA, and expressed as a percent relative to fgf-23^+/+/1α-Luc^+/− mice. Bars depict mean±SEM (n = 5 mice/group) *P<0.05, compared to fgf-23^+/+/1α-Luc^+/− mice.