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. 2013 Sep 3;8(9):e74235. doi: 10.1371/journal.pone.0074235

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© 2013 Gan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A demonstrates immunofluorescence images and their quantitative assessment demonstrating nuclear localization of FTO in cardiomyocytes and its upregulation by leptin whereas panel B shows identical data in myocytes transfected with siFTO illustrating suppression of FTO. Corresponding images of myocytes stained with the nuclear dye Hoechst 33342 as well as merged images are also presented. Quantitative data in panel C are presented as mean+SEM, N = 8. *P<0.05 from respective control (Ctl) group; +P<0.05 from respective group in the absence of siFTO (−siFTO). Lep, leptin; A, leptin receptor antagonist. Horizontal bar in bottom right images indicates 200 µm.