Table 8. The MIC range, MIC50, MIC90, and geometric mean for 14 Hong Kong and all 476 C. neoformans isolates for seven antifungals.
Isolates | Antifungal agent | MIC | |||
Range | MIC50 | Geometric Mean | MIC90 | ||
Clinical isolates from Hong Kong China (n = 14) | Amphotericine B | 0.5–1 | 0.5 | 0.416 | 1 |
5-Flucytosine | 1–8 | 4 | 2.895 | 8 | |
Fluconazole | 0.25–4 | 2 | 1.662 | 4 | |
Itraconazole | 0.031–0.25 | 0.125 | 0.086 | 0.25 | |
Voriconazole | <0.016–0.125 | 0.063 | 0.060 | 0.125 | |
Posaconazole | 0.031–0.125 | 0.125 | 0.083 | 0.125 | |
Isavuconazole | <0.016–0.063 | 0.031 | 0.028 | 0.063 | |
All C. neoformans isolates (n = 476) | Amphotericine B | 0.063–1 | 0.25 | 0.251 | 0.5 |
including those from Pan et al., 2012 [8] | 5-Flucytosine | <0.063–>64 | 4 | 3.483 | 8 |
Fluconazole | 0.125–32 | 2 | 2.294 | 4 | |
Itraconazole | <0.016–0.5 | 0.063 | 0.063 | 0.25 | |
Voriconazole | <0.016–0.5 | 0.063 | 0.049 | 0.125 | |
Posaconazole | <0.016–0.25 | 0.063 | 0.061 | 0.125 | |
Isavuconazole | <0.016–0.125 | 0.031 | 0.027 | 0.063 |