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. 2013 Sep 3;8(9):e72222. doi: 10.1371/journal.pone.0072222

Table 8. The MIC range, MIC50, MIC90, and geometric mean for 14 Hong Kong and all 476 C. neoformans isolates for seven antifungals.

Isolates Antifungal agent MIC
Range MIC50 Geometric Mean MIC90
Clinical isolates from Hong Kong China (n = 14) Amphotericine B 0.5–1 0.5 0.416 1
5-Flucytosine 1–8 4 2.895 8
Fluconazole 0.25–4 2 1.662 4
Itraconazole 0.031–0.25 0.125 0.086 0.25
Voriconazole <0.016–0.125 0.063 0.060 0.125
Posaconazole 0.031–0.125 0.125 0.083 0.125
Isavuconazole <0.016–0.063 0.031 0.028 0.063
All C. neoformans isolates (n = 476) Amphotericine B 0.063–1 0.25 0.251 0.5
including those from Pan et al., 2012 [8] 5-Flucytosine <0.063–>64 4 3.483 8
Fluconazole 0.125–32 2 2.294 4
Itraconazole <0.016–0.5 0.063 0.063 0.25
Voriconazole <0.016–0.5 0.063 0.049 0.125
Posaconazole <0.016–0.25 0.063 0.061 0.125
Isavuconazole <0.016–0.125 0.031 0.027 0.063