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. 2013 Sep 3;8(9):e72751. doi: 10.1371/journal.pone.0072751

Figure 4. Cofactor environment showing amino acid residues at 5 Å contact.

Figure 4

Cofactor including homocitric acid, α-His442, and α-Cys 275 ligands are shown as CPK spheres. Waters are red dot spheres. Dark green surface and sticks represent invariant residues. Light teal surface and sticks represent single variant residues. Bright orange surface and sticks represent multiple variant residues. (See Tables S9 and S10) A. Cofactor with α-Cys275 and α-His442 ligands. B. Invariant and single variant residues added. C Multiple variant residues added. Water sheet between homocitric acid and β-subunit is on the right. Amino acids that interact only by H-bond through water atoms are omitted. Figure was prepared using 3U7Q.pdb and Pymol (http://pymol.org/).