Figure 1. Therapeutic effects of anti-mouse CD115 mAb in the EL4 solid tumor model.

Tumor-bearing mice were treated with 10, 25 or 50 mg/kg of mAb AFS98 or PBS, IP, starting from day 7 after tumor implantation. A. Tumor volumes are shown as means ± SEM. * Mann-Whitney’s test p<0.05 compared with the tumor volumes of PBS-treated mice (n = 15). B. Percentages of surviving mice in each group. * Log-rank test p<0.05 compared with the PBS-treated mouse group (n = 15).