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. 2013 Sep 3;8(9):e73310. doi: 10.1371/journal.pone.0073310

Figure 2. Depletion of M2-polarized TAMs by anti-mouse CD115 mAb in EL4 solid tumors.

Figure 2

EL-4 tumors sampled at day 20 from mice treated with either PBS (A, C, E) or 50 mg/kg mAb AFS98 (B, D, F) were analyzed by IF with anti-F4/80 mAb (A, B), anti-CD163 mAb (C, D) or irrelevant isotype control (E, F). Blue : DNA; Red : F4/80+ macrophages (A, B) or CD163+ M2-type macrophages (C, D). Sections shown were obtained from one tumor representative of 3 analyzed per group. F4/80 (G) and CD163 (H) staining were quantified in the tumors shown in A-D.