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. 2013 Sep 3;8(9):e73088. doi: 10.1371/journal.pone.0073088

Figure 6. Microparticles (MPs) from active CD patients induce nitric oxide (NO) overproduction in mouse aorta.

Figure 6

Concentration-effect curves of 5-HT in the presence and in the absence of L-NA in aortic rings isolated from mice injected in vivo with vehicle (controls (CTL)) and MPs from HS (HSMPs) (A) and with MPs from active CD patients (active CDMPs) (B). Contraction are expressed in mN/mm. Results are given as mean ± SEM (n = 7–8). NO production (C) assessed by the amplitude of NO-Fe(DETC)2 complex signal and superoxide anion (O2 −) production (D) assessed by the amplitude of O2 –CMH complex signal in unit/weight in aorta from mice injected in vivo with vehicle (CTL), HSMPs and active CDMPs. Results are given as mean ± SEM (n = 5–7). **p<0.01; ***p<0.001 vs CTL.