Table 1.
Demographic, anthropometric and clinical characteristics of patients with NAFLD enrolled in NASH CRN studies by age group
| Characteristics | Age group
|
P† | |
|---|---|---|---|
| Non-elderly (18–64 years old) (N=735) | Elderly (≥ 65 years old) (N=61) | ||
| Demographics & lifestyle: | |||
| Male, n (%) | 295 (40%) | 14 (23%) | 0.01 |
| Age (mean years ± SD) | 47 ± 11 | 68 ± 3 | <0.001 |
| White, n (%) | 593 (84%) | 46 (78%) | 0.20 |
| Hispanic, n (%) | 98 (13%) | 7 (12%) | 0.84 |
| Ever smoked regularly, n (%)‡ | 263 (36%) | 31 (51%) | 0.03 |
| Clinical | |||
| Hypertension, n (%) | 337 (46%) | 42 (69%) | 0.001 |
| Cardiovascular disease (CVD), n (%)‡ | 33 (4%) | 11 (18%) | < 0.001 |
| Type 2 diabetes, n (%) | 174 (24%) | 15 (25%) | 0.88 |
| Metabolic syndrome, n (%) | 451 (61%) | 34 (56%) | 0.41 |
| Anthropometric (mean ± SD) | |||
| Body mass index (kg/m2) | 35 ± 6 | 32 ± 5 | < 0.001 |
| Waist circumference (cm) | 109 ± 14 | 103 ± 12 | < 0.001 |
| Hepatology panel§ (mean ± SD) | |||
| AST (U/L) | 54 ± 36 | 61 ± 44 | 0.20 |
| ALT (U/L) | 76 ± 52 | 67 ± 44 | 0.16 |
| AST/ALT ratio | 0.8 ± 0.4 | 1.0 ± 0.4 | < 0.001 |
| Alkaline phosphatase (ALK) (U/L) | 87 ± 33 | 94 ± 37 | 0.13 |
| GGT (U/L) | 70 ± 78 | 77 ± 75 | 0.53 |
| Albumin (g/dL) | 4.2 ± 0.4 | 4.2 ± 0.4 | 0.20 |
| Bilirubin, total (mg/dL) | 0.8 ± 0.4 | 0.8 ± 0.4 | 0.26 |
| Bilirubin, direct (mg/dL) | 0.1 ± 0.1 | 0.2 ± 0.2 | 0.03 |
| International normalized ratio | 1.0 ± 0.2 | 1.0 ± 0.1 | 0.18 |
| Other laboratory studies§ (mean ±SD) | |||
| Platelet count (1000/mm3) | 245 ± 71 | 218 ± 66 | 0.004 |
| Total cholesterol (mg/dL) | 195 ± 42 | 199 ± 44 | 0.48 |
| HDL cholesterol (mg/dL) | 43 ± 12 | 47 ± 11 | 0.01 |
| LDL cholesterol (mg/dL) | 119 ± 36 | 122 ± 38 | 0.65 |
| Triglycerides (mg/dL) | 178 ± 131 | 159 ± 79 | 0.08 |
| HbA1c (%) | 6.0 ± 1.1 | 6.0 ± 1.0 | 0.70 |
| Fasting serum glucose (mg/dL) | 103 ± 34 | 107 ± 27 | 0.31 |
| Fasting serum insulin (lU/mL) | 23 ± 19 | 19 ± 13 | 0.07 |
| HOMA-IR (mg/dL × lU/mL/405) | 6.0 ± 6.0 | 5.5 ± 4.4 | 0.34 |
| Ferritin (ng/mL) | 235 ± 264 | 326 ± 454 | 0.13 |
| APRI score‡ | 0.5 ± 0.4 | 0.7 ± 0.6 | 0.04 |
Participants enrolled in the NASH CRN with a biopsy within 1 year of enrollment.
P values (2-sided) determined from either a Fisher’s exact test for categorical variables or t-test for continuous variables
Ever smoked regularly defined as smoking at least 1 cigarette per day for a year; 4 non-elderly patients were missing values.
Cardiovascular disease defined as ever diagnosed with cerebrovascular or coronary heart disease.
APRI defined as (AST/ULN)/platelets × 100
Abbreviations: AST: aspartate aminotransferase, ALT: alanine aminotransferase, GGT: gamma glutamyl trans-peptidase, HDL: high density lipoprotein, LDL: low density lipoprotein, HbA1c: hemoglobin A1c, HOMA-IR: the homeostasis model assessment of insulin resistance index