Skip to main content
. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Hepatology. 2013 Oct 2;58(5):1644–1654. doi: 10.1002/hep.26465

Table 2.

Histological features of patients with NAFLD comparing elderly to non-elderly patients

Histological Feature* Age Group
P
Non-elderly (N=735) No. (%) Elderly (N=61) No. (%)
Steatosis:
 Grade 0.20
  0–1 (0%–33%) 309 (42.0%) 31 (50.8%)
  2 (>33%–66%) 252 (34.3%) 18 (29.5%)
  3 (>66%) 174 (23.7%) 12 (19.7%)
 Location (predominant) 0.02
  Zone 3 (central) 307 (41.8%) 15 (24.6%)
  Zone 1(periportal) 11 (1.5%) 0 (0.0%)
  Azonal 195 (26.6%) 26 (42.6%)
  Panacinar 221 (30.1%) 20 (32.8%)
 Microvesicular steatosis: present 74 (10.1%) 9 (14.8%) 0.27
Fibrosis:
 Stage:
  None (0) 200 (27.4%) 5 (8.2%) 0.001
  Mild/moderate ( zone 3), portal/periportal (1A, 1B, 1C) 209 (28.3%) 13 (21.3%)
  Zone 3 & periportal (2) 141 (19.3%) 16 (26.2%)
  Bridging (3) 122 (16.7%) 19 (31.0%)
  Cirrhosis (4) 61 (8.3%) 8 (13.1%)
 Advanced fibrosis: 0.002
  None (0), mild (1), moderate (2) 548 (75.0%) 34 (55.7%)
  Bridging (3) or cirrhosis (4) 183 (25.0%) 27 (44.3%)
Inflammation:
 Lobular inflammation (score) (no. foci per 200X field) 0.007
  0 to <2 foci (0–1) 392 (53.3%) 22 (36.1%)
  2 to 4 foci (2) 267 (36.3%) 26 (42.6%)
  >4 foci (3) 76 (10.3%) 13 (21.3%)
 Microgranulomas: present 603 (82.0%) 52 (82.3%) 0.60
 Large lipogranulomas: present 279 (38.0%) 33 (54.1%) 0.02
 Portal Inflammation (score) 0.23
  None (0) 111 (15.1%) 5 (8.2%)
  Mild (1) 466 (63.4%) 39 (63.9%)
  More than mild (2) 158 (21.5%) 17 (27.9%)
Liver cell injury:
 Ballooning (score): 0.004
  None (0) 251 (34.2%) 15 (24.6%)
  Few (1) 199 (27.1%) 9 (14.8%)
  Many (2) 285 (38.8%) 37 (60.7%)
 Acidophil bodies: many 215 (29.3%) 26 (42.6%) 0.04
 Pigmented macrophages: many 644 (87.6%) 54 (88.5%) 1.00
 Megamitochondria: many 106 (14.4%) 15 (24.6%) 0.04
Other findings
 Mallory Denk bodies: many 194 (26.4%) 32 (52.5%) < 0.001
 Glycogenated nuclei: many 392 (53.3%) 29 (47.5%) 0.42
 NAFLD Activity Score (NAS) 0.23
  0 – 4 384 (52.2%) 27 (44.3%)
  5 – 8 351 (47.8%) 34 (55.7%)
   Mean ± SD 4.38 ± 1.67 4.82 ± 1.69 0.05
Diagnostic classification:
 Steatohepatitis (diagnosis): 0.12
  Not steatohepatitis (0) 166 (22.6%) 10 (16.4%)
  Possible/borderline:
   Zone 3 pattern (1A) 148 (20.1%) 7 (11.5%)
   Zone 1, periportal (1B) 9 (1.2%) 0 (0.0%)
  Definite steatohepatitis (2) 412 (56.1%) 44 (72.1%)
 Definite NASH (yes) 412 (56.1%) 44 (72.1%) 0.02
*

Determination of histological features from centrally reviewed biopsies using the NASH CRN Scoring System9

P values determined from Fisher’s exact test or Cuzick non-parametric test for trend across ordered categories, except for NAS, a t-test was used

HHS Vulnerability Disclosure