Table 3.
Histological features of patients with definite NASH comparing elderly to non-elderly patients
| Histological Feature* | Age Group
|
P† | |
|---|---|---|---|
| Non-elderly (N=412) No. (%) | Elderly (N=44) No. (%) | ||
| Steatosis: | |||
| Grade | 0.01 | ||
| 0–1 (0%–33%) | 136 (33.0%) | 23 (52.3%) | |
| 2–3 (>33%) | 276 (67.0%) | 21 (47.7%) | |
| Location (predominant) | 0.07 | ||
| Zone 3 (central) | 152 (36.9%) | 9 (20.5%) | |
| Zone 1(periportal) | 2 (0.5%) | 0 (0.0%) | |
| Azonal | 119 (28.9%) | 20 (45.5%) | |
| Panacinar | 139 (33.7%) | 15 (34.1%) | |
| Microvesicular steatosis | 0.82 | ||
| Not present | 353 (85.7%) | 37 (84.1%) | |
| Present | 59 (14.3%) | 7 (15.9%) | |
| Fibrosis: | |||
| Stage: | 0.03 | ||
| None (0) | 32 (7.8%) | 1 (2.3%) | |
| Mild/moderate ( zone 3), portal/periportal (1A, 1B, 1C) | 133 (32.4%) | 7 (15.9%) | |
| Zone 3 & periportal (2) | 101 (24.6%) | 13 (29.6%) | |
| Bridging (3) | 107 (26.1%) | 15 (34.1%) | |
| Cirrhosis (4) | 37 (9.0%) | 8 (18.2%) | |
| Advanced fibrosis: | 0.03 | ||
| None (0), mild (1), moderate (2) | 266 (64.9%) | 21 (47.7%) | |
| Bridging (3) or cirrhosis (4) | 144 (35.1%) | 23 (52.3%) | |
| Inflammation: | |||
| Lobular inflammation (score) (no. foci per 200X field) | 0.08 | ||
| 0 to <2 foci (0–1) | 162 (39.3%) | 13 (29.6%) | |
| 2 to 4 foci (2) | 183 (44.4%) | 18 (40.9%) | |
| >4 foci (3) | 67 (16.3%) | 13 (29.6%) | |
| Microgranulomas: present | 357 (86.7%) | 40 (90.9%) | 0.64 |
| Large lipogranulomas: present | 172 (41.8%) | 29 (65.9%) | 0.002 |
| Portal Inflammation (score) | 0.69 | ||
| None (0) | 43 (10.4%) | 3 (6.8%) | |
| Mild (1) | 260 (63.1%) | 27 (61.4%) | |
| More than mild (2) | 109 (26.5%) | 14 (31.8%) | |
| Liver cell injury: | |||
| Ballooning (score)‡: many (2) | 276 (67.0%) | 37 (84.1%) | 0.03 |
| Acidophil bodies: many | 160 (38.8%) | 25 (56.8%) | 0.02 |
| Pigmented macrophages: many | 372 (90.3%) | 41 (93.2%) | 0.79 |
| Megamitochondria: many | 76 (18.5%) | 14 (31.8%) | 0.05 |
| Other findings: | |||
| Mallory Denk bodies: present | 186 (45.2%) | 32 (72.7%) | < 0.001 |
| Glycogenated nuclei: many | 171 (41.5%) | 23 (52.3%) | 0.20 |
| NAFLD Activity Score (NAS) | 0.72 | ||
| 0 – 4 | 111 (26.9%) | 13 (29.5%) | |
| 5 – 8 | 301 (73.1%) | 31 (70.5%) | |
| Mean ± SD | 5.36 ± 1.25 | 5.43 ± 1.37 | 0.73 |
*
Determination of histological features from centrally reviewed biopsies using the NASH CRN Scoring System9
†
P values determined from Fisher’s exact test or Cuzick non-parametric test for trend across ordered categories, except for NAS, a t-test was used
‡
1 non-elderly patient and 0 elderly patients had no ballooning