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Pioglitazone Pharmacokinetic Parameters by CYP2C8 Genotype Group
| Parameter |
CYP2C8*1/*1 (n = 9) |
CYP2C8*2 carriers (n = 8) |
P value |
|---|---|---|---|
| AUC0-∞ (ng*h/ml) | 7331 ± 2846 | 10431 ± 5090 | 0.15 |
| AUC0-∞/kg (ng*h/ml/kg) | 93 ± 43 | 148 ± 88 | 0.10 |
| AUC0-48 (ng*h/ml) | 7125 ± 2708 | 9923 ± 4797 | 0.18 |
| Cmax (ng/ml) | 808 ± 223 | 831 ± 290 | 0.90 |
| t1/2 (h) | 7.4 ± 2.7 | 10.5 ± 4.0 | 0.07 |
| Tmax (h) | 1.0 (0.5-2.0) | 1.5 (1.0-3.0) | 0.37 |
Data are expressed as mean ± SD or median (range).
