Table 2.

Association results for ADAS-cog in ADNI

Chr	BP	SNP	MAF	SNP Type	Gene	Beta	P
1	171557600	rs2421847	0.04	missense	PRRC2C	0.26	8.71E-07
1	240605052	rs12091371	0.07	intron	FMN2	0.17	6.70E-08
2	14987571	NA	0.03	NA	NA	−0.49	5.67E-07
2	16965493	NA	0.06	NA	NA	0.28	1.29E-06
2	80281173	rs6738962	0.04	intron	CTNNA2	0.18	1.17E-08
2	128396167	rs78022502	0.06	3′ UTR	LIMS2	0.23	1.69E-06
3	39513278	rs538867	0.03	intron	MOBP	0.26	1.01E-07
3	51095028	rs9857727	0.1	intron	DOCK3	0.18	9.70E-06
3	165493136	rs2668205	0.03	intron	BCHE	0.27	9.63E-06
4	5237153	rs78647349	0.04	intron	STK32B	0.3	5.24E-07
4	87931404	rs340635	0.03	intron	AFF1	0.23	2.18E-07
5	55510656	rs4700060	0.1	intron	ANKRD55	0.21	1.07E-08
5	109111327	rs113689198	0.03	intron	MAN2A1	0.3	9.65E-09
5	109221026	rs112724034	0.03	NA	PGAM5P1	0.31	8.51E-13
5	109230839	NA	0.03	NA	NA	0.38	1.03E-20
5	110719187	rs77636885	0.03	intron	CAMK4	0.3	1.80E-06
5	118435127	rs116348108	0.04	intron	DMXL1	0.28	8.91E-07
5	126729450	rs143954261	0.04	intron	MEGF10	0.29	8.11E-07
5	127382302	rs146579248	0.04	NA	FLJ33630	0.21	4.30E-07
5	153837106	rs148763909	0.03	3′ UTR	SAP30L	0.15	1.49E-08
6	78357637	NA	0.05	NA	NA	0.29	8.97E-08
6	116056915	NA	0.04	NA	NA	0.3	5.71E-08
6	124326227	rs117780815	0.03	intron	NKAIN2	0.31	6.28E-07
6	136288895	rs9494429	0.03	intron	PDE7B	0.23	5.97E-07
6	136368005	rs11154851	0.03	intron	PDE7B	0.25	1.14E-08
6	151102830	rs75253868	0.04	intron	PLEKHG1	0.26	2.24E-06
7	16707861	rs58370486	0.03	intron	BZW2	0.36	6.37E-11
7	16811139	rs73071801	0.04	intron	TSPAN13	0.33	9.97E-07
7	25161602	rs1861525	0.03	3′ UTR	CYCS	0.25	1.67E-07
7	37365196	rs2392492	0.04	intron	ELMO1	0.32	1.15E-06
7	43377276	rs17172199	0.08	intron	HECW1	0.28	1.09E-06
7	133747946	rs11770757	0.04	intron	EXOC4	0.16	4.76E-07
8	3088173	rs73660619	0.06	intron	CSMD1	0.26	7.45E-07
8	53214265	rs7009219	0.06	intron	ST18	0.16	5.12E-07
8	68761014	NA	0.05	NA	NA	0.28	8.81E-09
9	132939792	rs4836694	0.11	intron	NCS1	0.21	7.15E-07
10	64635265	NA	0.04	NA	NA	0.26	3.90E-10
10	122279476	rs118048115	0.04	intron	PPAPDC1A	0.34	6.41E-07
11	14224346	rs11023139	0.05	intron	SPON1	0.31	7.00E-11
11	14338703	rs61883963	0.06	intron	RRAS2	0.26	5.19E-07
11	14556220	rs34162548	0.05	intron	PSMA1	0.27	1.14E-06
11	37033930	NA	0.06	NA	NA	0.16	8.22E-07
11	110499253	rs326946	0.17	intron	ARHGAP20	0.16	6.81E-07
11	128185570	NA	0.03	NA	NA	0.31	8.92E-14
12	51878760	rs147845115	0.03	intron	SLC4A8	0.29	2.84E-07
12	94235165	rs61144803	0.04	intron	CRADD	0.16	5.02E-08
12	101221239	rs1399439	0.04	intron	ANO4	0.2	3.51E-07
13	61617648	NA	0.07	NA	NA	0.24	2.83E-09
13	93945858	rs143258881	0.03	intron	GPC6	0.29	6.73E-08
13	109473946	rs17393344	0.06	intron	MYO16	0.26	1.69E-08
14	95764564	rs115102486	0.03	intron	CLMN	0.31	2.28E-08
15	27712644	rs74006954	0.03	intron	GABRG3	0.28	2.74E-07
15	58730639	rs17301739	0.07	intron	LIPC	0.28	1.45E-06
16	24675589	rs8045064	0.05	NA	FLJ45256	0.21	4.27E-08
16	77876763	rs9934540	0.03	intron	VAT1L	0.25	3.55E-07
17	45888374	rs62076103	0.07	intron	OSBPL7	0.26	3.32E-07
17	45905622	rs62076130	0.06	intron	MRPL10	0.26	7.82E-07
17	45930539	rs4794202	0.08	intron	SP6	0.19	7.99E-08
17	47134762	NA	0.03	NA	NA	0.3	6.07E-11
17	48692082	rs117964204	0.04	intron	CACNA1G	0.28	9.44E-10
17	59292436	rs72832584	0.05	intron	BCAS3	0.3	1.14E-11
19	51422877	NA	0.05	NA	NA	0.34	3.00E-10
19	51430596	rs7245858	0.04	missense	LOC390956	0.28	2.03E-06
20	2384972	rs34972666	0.11	intron	TGM6	0.23	3.46E-08
22	44526105	rs75617873	0.03	intron	PARVB	0.17	5.01E-07

Type = type of SNP

BP = base pair location in release 19, build 135 of the human genome in the dbSNP database

SNPs in bold were genotyped

MAF = minor allele frequency in ADNI

Beta = Change in ADAS-cog per copy of the minor allele per month with AD, positive numbers indicate slower decline and negative numbers indicate more rapid decline

P = P-value after correction for a genomic inflation factor of 1.079