Figure 1.

Spatial structure, intrinsic connectivity, and fear-conditioning protocol for the LAd network model. A, The model consists of 800 principal cells and 200 interneurons populated randomly in the horn-shaped LAd. B, Fear-conditioning protocol. C, Average tone responses of plastic LAd cells during the different phases of the behavioral protocol. D, Example of tone responses generated by a plastic cell during habituation (top) and recall test (bottom). E, Repetitive firing dynamics of three types of model projection cells. F, Proportion of plastic cells among the three types of projection cells. G, Expected (white) and observed (black) numbers of model plastic cells for the control, CREB⁺, and CREB⁻ cases. Competition biases the observed numbers toward the control value.