Figure 1.

Deep brain stimulation of the nucleus accumbens shell, but not core, attenuates cocaine priming-induced reinstatement. A, C, Mean (±SEM) active and inactive lever responses from reinstatement sessions with 0 or 150 μA of stimulation aimed at the shell (A) or core (C). DBS began immediately following administration of 10 mg/kg (i.p.) cocaine and continued throughout the 2 h reinstatement session. B, Time course of active lever responding from 0 or 150 μA stimulation of the accumbens shell. D, Electrode placements from both the shell (closed circles) and core (open circles). The values are in millimeters, relative to bregma. *p < 0.05 0 μamps compared with 150 μamps. There were five to eight animals per group.