Figure 2.

Baclofen-muscimol or lidocaine microinjected into the core but not the shell of the nucleus accumbens attenuated cocaine priming-induced reinstatement. A–D, Mean (±SEM) active and inactive lever responses from reinstatement sessions with saline or baclofen and muscimol microinjected into the nucleus accumbens shell (A) or core (B) and lidocaine microinjected into the shell (C) or core (D). Cocaine (10 mg/kg, i.p.) was administered 10 min following the baclofen and muscimol microinjection or immediately following the lidocaine injection. *p < 0.05 compared to saline microinjections. There were 7–12 animals per group.