Figure 4.

Baclofen and muscimol microinjected into the infralimbic, prelimbic, and cingulate cortex attenuates cocaine priming-induced reinstatement. A–C, Mean (±SEM) active and inactive lever responding from a reinstatement session in which baclofen and muscimol or saline was microinjected 10 min before a 10 mg/kg cocaine priming injection into the cingulate cortex (A), the prelimbic cortex (B), or the infralimbic cortex (C). D, Cannulae placements from infrlimbic (open circles), prelimbic (gray circles), and cingulate (black circles). The values are in mm relative to bregma. *p < 0.05 Baclofen and muscimol compared to saline microinjections. There were 9–11 animals per group.