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Doxycycline Toxicity in mice
| Time (Hours) | 0.25 | 0.5 | 1.0 | 2.0 | 4.0 | 6.0 | 8.0 | 24.0 |
|---|---|---|---|---|---|---|---|---|
| Dose (mg/kg) | N/T | N/T | N/T | N/T | N/T | N/T | N/T | N/T |
| 150 | 0/4 | 1/4 death | 0/4 | 0/4 | 1/4 death | |||
| 300 | 1/8 motor imp | 1/8 motor imp | 0/8 | 1/8 motor imp | 4/8 death | 7/7 death | 5/5 death | |
| 500 | 7/8 motor imp | 4/8 motor imp | 5/8 motor imp | 3/8 motor imp | 8/8 death | |||
N/T: number of animals showing toxic effect / number of animals tested
Motor Imp: motor impairment on rotarod test
Control injection of 0.5% methylcellulose showed no toxicity
