Table 1. Relaxatory effects induced by ethanol extracts obtained from A. graveolens on the contraction induced by NE (1×10−7 mol/L).
Vasorelaxant agent | With endothelium (E+) |
With out endothelium (E+) |
|||
EC50 (µg/mL) | Emax (%) | EC50 (µg/mL) | Emax (%) | ||
Carbachol | 0.002 | 100.00±1.01 | ND | ND | |
SNP | ND | ND | 0.044 | 72.80±9.24 | |
MEAG | 7.32 | 58.39±7.39 | 47.72 | 35.10±2.45 | |
HEAG | 51.90 | 26.09±3.93 | 40.42 | 34.64±5.45 | |
EAEAg** | 15.05 | 69.79±6.58 | 43.15 | 79.92±6.67* | |
DEAG** | 47.60 | 69.49±6.28 | 49.45 | 66.58±3.67 |
Results are presented as mean±SEM, n=6. *: P<0.05 compared with aortic rings with endothelium, **: P<0.05 compared with MEAg and HEAg. MEAg: Methanol extract from A. graveolens. HEAg: Hexane extract from A. graveolens. EAEAg: Ethyl Acetate extract from A. graveolens. DEAg: Dichloromethane extract from A. graveolens. ND: Non determinate.