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Inhibition of PAK blocks platelet aggregation by thrombin. Replicate samples of washed human platelets (2 × 108/ml) were incubated with vehicle (DMSO) or increasing concentrations of IPA-3 or 10 μM PIR 3.5 before stimulation with thrombin (0.07 U/ml), and the change in optical density indicative of platelet aggregation was recorded. Results are representative of 4 separate experiments.
