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. 2013 Jul 9;305(5):E632–E640. doi: 10.1152/ajpendo.00281.2013

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Fig. 2. — NPY/AgRP neurons respond to baclofen, a GABA_B agonist. A: baclofen elicits a concentration-dependent outward current in NPY/AgRP neurons, reaching its maximum effectiveness at ∼30 μM. B: intact male and hypoestrogenic female NPY/AgRP neurons show a statistically similar EC₅₀ to baclofen of 4.3 and 4.7 μM, respectively. C: baclofen reversibly hyperpolarizes NPY/AgRP cells, inhibiting firing. D: I-V relationships before and after application of 10 μM baclofen shows a reversal near the calculated E_K.