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. 2013 Jun 26;305(6):C643–C653. doi: 10.1152/ajpcell.00003.2013

Fig. 7.

Fig. 7.

Foxo1 activity decreases the expression of the skeletal muscle sodium channel Nav1.4. A: Western blot analysis of whole cell homogenates prepared from FDB muscles using Nav1.4 and GAPDH antibodies. A: expression of Nav1.4 and GAPDH in fibers expressing GFP, fibers treated with IGF-1 expressing GFP fibers expressing Foxo1-GFP, and fibers treated with IGF-1 expressing Foxo1-GFP. Blot is representative of 4 independent experiments (4 mice per group). B: quantification of Western blots show that fibers expressing Foxo1-GFP have a decreased expression of Nav1.4 compared with fibers expressing GFP. *P < 0.05, compared with control GFP fibers. IGF-1 treatment of fibers expressing Foxo1-GFP recovers the loss of expression of Nav1.4. **P < 0.05 compared with Foxo1-GFP fibers.