Fig. 3.

AA activates a TEA-insensitive K⁺ current in pHUSMC and HEK293-hTREK-1 cells. A: time course of whole cell voltage-clamp recording from pHUSMC and HEK293-hTREK-1 cells at +80 and −80 mV showing reversible activation of outward current by AA (10 μM). B: representative whole cell current density traces in response to voltage ramps from +80 to −80 mV before treatment (initial) and in the presence of AA in standard and high-K⁺ bath solutions in pHUSMC and HEK293-hTREK-1 cells. C: mean current density in response to 20-mV voltage steps from −100 to +100 mV before (initial) and after AA treatment in pHUSMC and HEK293-hTREK-1 cells. *P < 0.05. Insets: representative whole cell current traces before and after AA treatment.