Table 1.
Baseline characteristics of the 34 chronic liver disease patient
| No-AKI n = 16 | AKI n = 18 | P value | |
|---|---|---|---|
| Baseline variables | |||
| Age (years) | 48 ± 12 | 53 ± 14 | 0.27 |
| Gender (M:F) | 8:12 | 8:6 | 0.5 |
| Ascites* | 9:7 | 13:5 | 0.54 |
| MAP (mm Hg) | 82 (10) | 79 (14) | 0.51 |
| HR (beats/min) | 90 (13) | 96 (13) | 0.2 |
| MELD | 18 (13–22) | 22 (15–26) | 0.28 |
| CP score | 11 (9–11) | 10 (9–11) | 0.86 |
| SOFA score | 4 (2) | 10 (3) | 0.003 |
| Serum creatinine (μmol/L) | 68 ± 22 | 78 ± 20 | 0.18 |
| eGFR (mL/min/1.73 m2) | 96 (81–134) | 66 (55–96) | 0.01 |
| Iohexol GFR (mL/min/1.73 m2)† | 74 ± 28 | 52 ± 22 | 0.02 |
| Cystatin C GFR | 73 ± 17 | 60 ± 22 | 0.09 |
| Urine protein:creatinine (mg/mmol) | 17 (13–29) | 55 (36–189) | 0.0005 |
| Sodium (mmol/L) | 135 ± 6 | 136 ± 7 | 0.6 |
| Bilirubin (μmol/L) | 94 (51–213) | 106 (40–393) | 0.65 |
| INR | 2.1 (1.5–2.7) | 2.0 (1.8–2.5) | 0.96 |
| Platelets (×109/L) | 112 (78–166) | 96 (73–137) | 0.27 |
| Albumin (g/L) | 31 ± 5 | 27 ± 7 | 0.56 |
| CRP (mg/L) | 11.5 (6–32) | 54 (9–144) | 0.07 |
| Outcome | |||
| RRT | 0:16 | 12:6 | 0.0002 |
| ICU admission | 6:12 | 12:4 | <0.05 |
| Alive:Dead | 15:1 | 6:12 | 0.001 |
| Liver transplantation | 9:7 | 16:2 | 0.08 |
AKI, acute kidney injury; CP, Child-Pugh; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; HR, heart rate; INR, international normalised ratio; MAP, mean arterial pressure; MELD, Model for End-Stage Liver Disease; RRT, renal replacement therapy; SOFA, Sequential Organ Failure Assessment.
Independent t-test for parametric data with standard deviation in parenthesis and Mann–Whitney U-test for nonparametric data with interquartile range in parenthesis.
Chi-square for categorical data.
*
Grade 2 to 3 ascites defined according to International Ascites Club.24
†
Twenty-seven iohexol clearance-derived GFR measurements, four patients declined the test.