Fig. 4.

Summarized results of the dose-dependent effects of ondansetron on 1) bladder capacity of the bladder irritated by AA and 2) the PNS-induced increase in bladder capacity at two intensities of stimulation (n = 12 cats). The x-axis indicates intravenous doses of ondansetron and also repeated intravenous injections of vehicle at the same volumes and at the same time intervals as the drug injections (n = 5 cats, vehicle control). Vehicle injections did not change bladder capacity. The bladder capacity was normalized to the saline control capacity before any treatment. PNS: 5 Hz, 0.2 ms; T = 0.4–1.4 V. *Significantly different from the AA control (by two-way ANOVA); #significantly different from the bladder capacity measured before ondansetron treatment (i.e., at 0 mg/kg ondansetron) (by one-way ANOVA). Note that the open symbols represent no PNS during the CMG.