Fig. 5.

AMPK agonist abrogates fibrosis and kidney lesions at 30 days A/I. A: low power light microscopy of a representative Masson's trichrome stained 30-day A/I kidney reveals extensive kidney fibrosis in both cortex and medulla. B: high-power light microscopy demonstrates fibrosis in glomeruli and interstitium of cortex and medulla in the 30 day A/I kidney, as well as glomerular and tubular lesions. AMPK agonist metformin (MET) prevents fibrosis and lesions in A/I glomeruli and interstitium (A and B). C: graphic representation and quantification of fibrosis. Data are expressed as means ± SE. *P < 0.01 vs. all treated groups.