Fig. 5.

STRING pathway analysis of proteins that are increased in the proximal convoluted tubule during acidosis. MS data collected from the cytosolic, mitochondrial (11), and apical membrane (44) studies were included for this analysis. Each individual protein is color coded to illustrate whether they were identified in the analysis of the brush border membrane (blue), mitochondrial (green) or cytosolic (red) fraction. Thicker lines are indicative of higher evidence of association. All proteins are labeled by their gene name. The identified groupings of interactive proteins participate in ammoniagenesis, hydrogen ion transport, retinol metabolism and fatty acid metabolism.