Fig. 6.

Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) pathway analysis of proteins that are decreased in the proximal convoluted tubule during acidosis. MS data collected from the cytosolic, mitochondrial (11), and apical membrane (44) studies were included for this analysis. Each individual protein is color coded to illustrate whether it is identified in the analysis of the brush-border membrane (blue), mitochondrial (green), or cytosolic (red) fraction. Individual proteins are labeled by gene name, and thicker lines represent more evidence of association. This analysis indicated that renal metabolism of phenylalanine may be decreased during metabolic acidosis.