Table 1.
List of 25 proteins identified during LC/MS/MS with the highest number of spectral counts
| Mean Spectral Counts ± SE |
|||||||
|---|---|---|---|---|---|---|---|
| Protein Name | UniProt Entry Name | UniProt Accession | Gene Name | Molecular Mass | Control | 1 day | 7 day |
| Hydroxyacid oxidase 2 | HAOX2_RAT | Q07523 | Hao2 | 39 kDa | 735.0 ± 141.6 | 1,001.0 ± 178.2 | 778.0 ± 87.2 |
| α-Enolase | ENOA_RAT | P04764 | Eno1 | 47 kDa | 562.7 ± 184.8 | 671.3 ± 151.2 | 466.7 ± 62.1 |
| Fructose-bisphosphate aldolase | Q66HT1_RAT | Q66HT1 | Aldob | 40 kDa | 457.0 ± 65.3 | 446.3 ± 47.5 | 559.7 ± 26.2 |
| Uncharacterized protein | D4AD25_RAT | D4AD25 | Cltc | 192 kDa | 309.3 ± 77.8 | 491.3 ± 59.5 | 389.3 ± 56.3 |
| Fructose-1,6-bisphosphatase 1 | F16P1_RAT | P19112 | Fbp1 | 40 kDa | 376.3 ± 90.6 | 417.3 ± 51.2 | 360.0 ± 23.0 |
| Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | PCKGC_RAT | P07379 | Pck1 | 69 kDa | 107.3 ± 23.1 | 644.3 ± 13.6 | 344.3 ± 55.8 |
| Actin, cytoplasmic 2 | ACTG_RAT | P63259 | Actg1 | 42 kDa | 303.0 ± 41.8 | 300.7 ± 41.3 | 243.3 ± 22.9 |
| Tubulin β-4B chain | TBB4B_RAT | Q6P9T8 | Tubb4b | 50 kDa | 271.3 ± 40.7 | 303.3 ± 16.2 | 230.7 ± 3.8 |
| Glyceraldehyde-3-phosphate dehydrogenase | D3ZGY4_RAT | D3ZGY4 | Gapdh-ps2 | 36 kDa | 276.7 ± 16.0 | 273.3 ± 29.9 | 240.3 ± 43.0 |
| Tubulin β-5 chain | TBB5_RAT | P69897 | Tubb5 | 50 kDa | 250.7 ± 40.1 | 267.0 ± 32.1 | 223.7 ± 17.8 |
| Major urinary protein | MUP_RAT | P02761 | N/A | 21 kDa | 328.0 ± 152.5 | 99.7 ± 27.9 | 249.7 ± 136.9 |
| Tubulin α-1C chain | TBA1C_RAT | Q6AYZ1 | Tuba1c | 50 kDa | 189.0 ± 64.0 | 254.3 ± 55.1 | 211.0 ± 39.1 |
| Tubulin α-4A chain | TBA4A_RAT | Q5XIF6 | Tuba4a | 50 kDa | 181.7 ± 60.7 | 237.3 ± 51.8 | 195.7 ± 43.0 |
| Glutathione S-transferase α-1 | GSTA1_RAT | P00502 | Gsta1 | 26 kDa | 200.0 ± 29.1 | 213.0 ± 8.0 | 201.7 ± 42.2 |
| Uncharacterized protein | D3ZXY4_RAT | D3ZXY4 | Aldh8a1 | 53 kDa | 202.0 ± 26.9 | 211.0 ± 18.0 | 184.7 ± 12.8 |
| Tubulin β-2A chain | TBB2A_RAT | P85108 | Tubb2a | 50 kDa | 247.0 ± 38.6 | 187.0 ± 93.6 | 153.3 ± 76.7 |
| Glutathione S-transferase α-3 | GSTA3_RAT | P04904 | Gsta3 | 25 kDa | 157.0 ± 52.5 | 216.7 ± 52.1 | 197.3 ± 73.7 |
| Malate dehydrogenase, cytoplasmic | MDHC_RAT | O88989 | Mdh1 | 36 kDa | 159.3 ± 63.8 | 225.7 ± 60.7 | 147.7 ± 29.6 |
| Catalase | CATA_RAT | P04762 | Cat | 60 kDa | 129.7 ± 20.2 | 195.0 ± 31.5 | 163.3 ± 20.3 |
| Argininosuccinate synthase | ASSY_RAT | P09034 | Ass1 | 46 kDa | 155.0 ± 36.8 | 181.0 ± 32.3 | 147.7 ± 15.6 |
| Alcohol dehydrogenase [NADP+] | AK1A1_RAT | P51635 | Akr1a1 | 37 kDa | 179.7 ± 74.7 | 132.3 ± 24.5 | 115.7 ± 42.1 |
| Transketolase, isoform CRA_a | G3V826_RAT | G3V826 | Tkt | 71 kDa | 104.3 ± 12.8 | 119.7 ± 6.1 | 118.0 ± 36.2 |
| Heat shock protein HSP 90-β | HS90B_RAT | P34058 | Hsp90ab1 | 83 kDa | 90.0 ± 18.8 | 136.0 ± 18.4 | 109.3 ± 19.4 |
| Aflatoxin B1 aldehyde reductase member 3 | ARK73_RAT | P38918 | Akr7a3 | 37 kDa | 117.0 ± 22.6 | 98.3 ± 36.1 | 107.7 ± 13.0 |
| Isocitrate dehydrogenase [NADP] cytoplasmic | IDHC_RAT | P41562 | Idh1 | 47 kDa | 103.0 ± 49.7 | 101.7 ± 17.7 | 63.7 ± 8.7 |
LC/MS/MS, liquid chromatography tandem mass spectrometry.